Pancreatic ductal adenocarcinoma (PDAC) remains a major challenge in cancer medicine. The aggressive tumor biology and remarkable resistance to conventional anti-tumor treatments are reflected in a 5-year PDAC survival rate of less than 8%. Despite significant scientific and clinical efforts the dismal prognosis of PDAC has remained unchanged for almost 30 years, and PDAC has been predicted to become the second leading cause of cancer related death within this decade.

Our Clinical Research Unit 5002 (CRU 5002) focuses on defined molecular subgroups of PDAC and explores subtype-specific genome dynamics and their implications on PDAC progression and therapy resistance. We believe that our findings can provide unique and novel avenues to refine PDAC treatment strategies towards stratification-based precision medicine, thus improving the outcome of PDAC patients.

About the CRU 5002

Projects and contact information

Our Concept

The CRU 5002 aims at improving our understanding of subtype specificity in PDAC biology and therapy resistance and at creating solid foundations for stratification-based tailored treatment strategies in PDAC.

Scientific and Central Projects

Our projects aim at defining the mechanisms, functional relevance and therapeutic potential of altered genome dynamics in selected PDAC subtypes.

Our Team

All of the CRU 5002's staff at a glance. If you require any further information regarding the CRU 5002, please do not hesitate to contact us. 


15/09/2021, 4:00 pm

Speaker: Prof. Günter Schneider (Göttingen)

Topic: Precision Oncology in PDAC?

29.09.2021, 4:00 pm

Speaker: Prof. Florian Greten (Frankfurt)

Topic: Cell Plasticity in Colorectal Cancer

13.10.2021, 4:00 pm

Speaker: Matthias Wirth (Berlin)

Topic: Expression of the BH3-only protein NOXA drives synthetic lethality to RUNX1 inhibition in pancreatic cancer

registration:  kfo5002(at)

News and upcoming events


Workshops 2021

Workshops for scientists in september and october

Contact information

Contact persons at a glance


Prof. Dr. med. Volker Ellenrieder

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  • Head of the Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology

    Head of the Comprehensive Cancer Center Göttingen


Prof. Dr. med. Elisabeth Heßmann

contact information

Scientific Assistant

Alexander Müller

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